Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

Author: Gok Kashicage
Country: Guinea-Bissau
Language: English (Spanish)
Genre: Love
Published (Last): 26 February 2013
Pages: 495
PDF File Size: 14.11 Mb
ePub File Size: 10.24 Mb
ISBN: 486-8-90013-782-5
Downloads: 47957
Price: Free* [*Free Regsitration Required]
Uploader: Mabei

Leg Ulcers and recurrent cellulitis. Amiodarone and drugs which prolong the QT interval can interact with many antibiotics. Is it chronic changes of venous stasis and chronic ulceration?

Are they suitable for compression? Colonisation is likely in leg ulcers. Doses are oral and for adults unless otherwise stated. Review antibiotics after culture results.

A total of patients were recruited. Please refer to our Drug Interactions Table for further information. Antibiotics do not improve healing unless active infection.

Penicillin to prevent recurrent leg cellulitis.

In patients with recurrent cellulitis of cellylitis leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped. N Engl J Med. Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue.

Penecillin to prevent leg cellulitis NEJM ; Baseline characteristics were similar in the two groups.

The primary outcome was the time to a first recurrence. Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy.

Leg Ulcers and recurrent cellulitis –

Bilateral cellulitis is uncommon. Skip to main content. Comment in N Engl J Med. Many antibiotics increase the risk of bleeding with anticoagulants.

Overall, participants in the penicillin group had fewer repeat episodes than those in the placebo group vs. Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only.

Penicillin to prevent recurrent leg cellulitis.

The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group. Comments from Expert Advisory Committee Antibiotics do not improve healing unless active infection.

We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis. Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. We conducted nrjm double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland.

Leg Ulcers and recurrent cellulitis

Refer for specialist cellhlitis if severe infection Is it cellulitis? Statins can interact with some antibiotics and increase the risk of rhabdomyolysis. Prophalactic antibiotics for the prevention of cellulitis erysipelas of the leg: Participants were followed for up to 3 years.